Programme

• Sun
• Mon
• Tue
• Wed
• Thu
• Fri
• Sat

• Sunday, 10 April
  16:30-17:30	Arrival and registration
  17:30	Welcome ceremony Introduction to the school, general information, and assignment of students to Agora teams
  18:30	Welcome drinks followed by dinner

• Monday, 11 April
  9:00-9:45	Eric Newman A historical overview of astrocyte function [30 min + 15 min discussion]
  9:45-10:30	Richard Robitaille Excitability of astrocytes: calcium signal [30 min + 10 min discussion]
  10:30-11:00	Coffee break
  11:00-11:45	Giorgio Carmignoto Optogenetic tools to study in vivo astrocytes [30 min + 10 min discussion]
  11:45-12:10	Student presentations Vanessa Sardinha (Braga, Portugal) The influence of gliotransmission on the cognitive function Dimitri Ryczko (Montreal, QC, Canada) Role of astrocytes in defining functional compartments in the mastication central pattern generator
  12:10-12:40	Agora • Preparation (1)
  12:40-14:00	Lunch break
  14:00-14:35	Student presentations Francesco Petrelli (Lausanne, Switzerland) VMAT2 in astrocytes regulates morphology of pyramidal neurons in developing PFC by modulating extracellular levels of dopamine Weida Shen (Paris, France) Release of glutamate and ATP induced by optogenetic activation of astrocytes Thomas Papouin (Boston, MA, USA) Cholinergic transmission tunes the gating of NMDA receptors to vigilance-state through astrocytic α7nAChR
  14:35-15:20	Dmitri Rusakov Monitoring nanomolar intracellular Ca2+ with time-resolved fluorescence microscopy? [30 min + 10 min discussion]
  15:20-16:15	Student presentations Franziska Müller (Hannover, Germany) Serotonergic signaling and impact of small GTPases in astrocytes Michelle Corkrum (Minneapolis, MN, USA) The effects of cocaine on astrocyte-neuron signaling in the nucleus accumbens Liliya Andrianova (Coventry, UK) Interactions of astrocytic ionic fluxes and physiological functions Maroussia Hennes (Leuven, Belgium) The role of gliotransmission in ME-induced plasticity in mouse visual cortex Ophélia Le Thuc (Munich, Germany) Astrocytic insulin signaling couples brain glucose uptake with nutrient availability
  16:15-16:35	Coffee break
  16:35-17:20	Alfonso Araque Specific tools for astrocyte stimulation [30 min + 10 min discussion]
  17:20-18:05	Marie-Ève Tremblay High spatial resolution analyses of glial cells with electron microscopy [30 min + 10 min discussion]
  18:05-19:00	Student presentations Justin Lines (Minneapolis, MN, USA) Astral-neural networks are coordinated during rhythmic local field potential activity Camille Philippot (Bonn, Germany) How do glial cells impact neuronal signalling in the thalamus? Cynthia Solek (Montreal, QC, Canada) The role of microglia-mediated inflammation in neuronal development in vivo Sebastien Barbat (Montreal, QC, Canada) Aging of the neuromuscular junction: role of glial cells in the modulation and regulation of the motor output Kanchan Bisht (Quebec, QC, Canada) Dark microglia: a new phenotype implicated in the pathological remodelling of neuronal circuits
  20:00	Dinner

• Tuesday, 12 April
  9:00-9:55	Student presentations Luisa Lange Canhos (Munich, Germany) Self-renewal capacity of reactive astrocytes in vivo Víctor Danelon (Córdoba, Argentina) Astrocytes mediate neuroprotection in a model of status epilepticus, modulating protease calpain activity in neurons Olesia Ignatenko (Helsinki, Finland) Knockout of mitochondrial DNA helicase in mouse astrocytes leads to glia activation and spongiotic encephalopathy Annamaria Lia (Padua, Italy) Exploring the role of astrocyte Ca2+ signaling in Alzheimer's disease Laura Civiero (Padua, Italy) LRRK2 deficiency in astrocytes impacts neuronal development in vitro
  9:55-10:40	Frank Kirchhoff Transgenic mouse models for astrocyte and NG2 glia research [30 min + 10 min discussion]
  10:40-11:10	Coffee break
  11:10-12:40	Student presentations Eric Martineau (Montreal, QC, Canada) Alteration of glial properties at the NMJ may hinder reinnervation in amyotrophic lateral sclerosis Carmen Muñoz-Ballester (Valencia, Spain) Astrocytic glutamate uptake is decreased in Lafora disease due to a change in GLT-1 cellular localization Eelke Brouwers (Amsterdam, Netherlands) Linking deficits in astrocyte chloride channels to disease phenotypes in the white matter disease MLC Ambra Del Grosso (Pisa, Italy) Galactosylceramidase (GALC) enzymatic activity and psychosine accumulation in central and peripheral nervous system cells and tissues from wild-type and Twitcher mice Emma van Kessel (Utrecht, Netherlands) Role of glioneuronal transmission and the cerebral glial network in neuro-cognitive functioning in patients with gliomas Anna Tishkina (Moscow, Russia) Glial changes in response to chronic stress Jinar Rostami (Uppsala, Sweden) Accumulation and spreading of α-synuclein oligomers in human astrocytes Martina Gabrielli (Milan, Italy) Active endocannabinoids are released from microglia in association with extracellular vesicles
  12:40-14:00	Lunch break
  14:00-14:45	Gian Michele Ratto Making invisible things visible: fluorescent reporters of cellular inner life [30 min + 10 min discussion]
  14:45-15:40	Student presentations Bronac Flanagan (Derry, UK) Computational modelling of the glutamate (GABA) – glutamine cycle in epilepsy Tanja Paavilainen (Tampere, Finland) Effects of temporal maturation and development of astrocytes in the functional properties of human neuronal networks in vitro Franziska Oschmann (Berlin, Germany) A mathematical model of calcium signals in astrocytes induced by uptake of synaptically released glutamate Kerstin Lenk (Tampere, Finland) Modeling presynapse-astrocyte interactions at network level Flora Vasile (Paris, France) Astroglial Pannexin hemichannels modulate neuronal network activity
  15:45-19:00	Agora • Preparation (2) [with coffee]
  20:00	Dinner

• Wednesday, 13 April
  9:00-9:45	Elly Hol Astrocytes in brain disorders: tools to study molecular and functional changes [30 min + 10 min discussion]
  9:45-10:30	Marie-Ève Tremblay Structural interactions between microglia and synapses in contexts of neuroinflammation [30 min + 10 min discussion]
  10:30-11:00	Coffee break
  11:00-11:45	Giovanni Marsicano Roles of astroglial cannabinoid CB1 receptors [30 min + 10 min discussion]
  11:45-12:30	Dmitri Rusakov Signal integration by astroglia: in search for keys [30 min + 10 min discussion]
  12:30-14:00	Lunch break
  14:00	Departure to Ravenna Sightseeing and guided tours, followed by dinner Return to Bertinoro after dinner

• Thursday, 14 April
  9:00-9:45	Gian Michele Ratto When glia goes bad: glioblastoma [30 min + 10 min discussion]
  9:45-10:30	João Filipe Oliveira The involvement of astrocytes in cognitive processing [30 min + 10 min discussion]
  10:30-11:00	Coffee break
  11:00-11:45	Giorgio Carmignoto Unique properties of the astrocyte response to gabaergic interneurons [30 min + 10 min discussion]
  11:45-12:30	Giovanni Marsicano A cannabinoid link between mitochondria and memory [30 min + 10 min discussion]
  12:30-14:00	Lunch break
  14:00-14:45	Frank Kirchhoff (Patho)-Physiological properties of astrocytes in vivo [30 min + 10 min discussion]
  14:45-15:30	Alfonso Araque Circuit-specific synaptic regulation by astrocytes [30 min + 10 min discussion]
  15:30-19:00	Agora • Preparation (3) [with coffee]
  20:00	Dinner

• Friday, 15 April
  9:00-9:40	Sebastien Thuault (Senior Editor, Nature Neuroscience) An insider’s guide to scientific publishing [30 min + 10 min discussion]
  9:40-10:20	Eric Newman Astrocyte regulation of blood flow in the CNS: fact or fantasy? [30 min + 10 min discussion]
  10:20-11:00	Elly Hol Reactive astrocytes in Alzheimer’s disease and stroke: do they affect neuronal communication? [30 min + 10 min discussion]
  11:00-11:30	Coffee break
  11:30-12:10	Marie-Ève Tremblay Microglial interactions with astrocytes in health and disease [30 min + 10 min discussion]
  12:10-12:50	Richard Robitaille Decoding the functional state of the neuromuscular junction by glial cells in health and disease [30 min + 10 min discussion]
  13:00-14:30	Lunch break
  14:30-19:30	Agora [with coffee]
  19:30-20:00	General discussion, Concluding Remarks, Questionnaires
  20:30	Farewell Dinner

• Saturday, 16 April
  	Departure