Astrocyte School

Bertinoro, Italy
10-16 April 2016


  • Sunday, 10 April

    16:30-17:30 Arrival and registration
    17:30 Welcome ceremony
    Introduction to the school, general information, and assignment of students to Agora teams
    18:30 Welcome drinks followed by dinner
  • Monday, 11 April

    9:00-9:45 Eric Newman
    A historical overview of astrocyte function
    [30 min + 15 min discussion]
    9:45-10:30 Richard Robitaille
    Excitability of astrocytes: calcium signal
    [30 min + 10 min discussion]
    10:30-11:00 Coffee break
    11:00-11:45 Giorgio Carmignoto
    Optogenetic tools to study in vivo astrocytes
    [30 min + 10 min discussion]

    Student presentations

    Vanessa Sardinha (Braga, Portugal)
    The influence of gliotransmission on the cognitive function

    Dimitri Ryczko (Montreal, QC, Canada)
    Role of astrocytes in defining functional compartments in the mastication central pattern generator

    12:10-12:40 Agora • Preparation (1)
    12:40-14:00 Lunch break

    Student presentations

    Francesco Petrelli (Lausanne, Switzerland)
    VMAT2 in astrocytes regulates morphology of pyramidal neurons in developing PFC by modulating extracellular levels of dopamine

    Weida Shen (Paris, France)
    Release of glutamate and ATP induced by optogenetic activation of astrocytes

    Thomas Papouin (Boston, MA, USA)
    Cholinergic transmission tunes the gating of NMDA receptors to vigilance-state through astrocytic α7nAChR

    14:35-15:20 Dmitri Rusakov
    Monitoring nanomolar intracellular Ca2+ with time-resolved fluorescence microscopy?
    [30 min + 10 min discussion]

    Student presentations

    Franziska Müller (Hannover, Germany)
    Serotonergic signaling and impact of small GTPases in astrocytes

    Michelle Corkrum (Minneapolis, MN, USA)
    The effects of cocaine on astrocyte-neuron signaling in the nucleus accumbens

    Liliya Andrianova (Coventry, UK)
    Interactions of astrocytic ionic fluxes and physiological functions

    Maroussia Hennes (Leuven, Belgium)
    The role of gliotransmission in ME-induced plasticity in mouse visual cortex

    Ophélia Le Thuc (Munich, Germany)
    Astrocytic insulin signaling couples brain glucose uptake with nutrient availability

    16:15-16:35 Coffee break
    16:35-17:20 Alfonso Araque
    Specific tools for astrocyte stimulation
    [30 min + 10 min discussion]
    17:20-18:05 Marie-Ève Tremblay
    High spatial resolution analyses of glial cells with electron microscopy
    [30 min + 10 min discussion]

    Student presentations

    Justin Lines (Minneapolis, MN, USA)
    Astral-neural networks are coordinated during rhythmic local field potential activity

    Camille Philippot (Bonn, Germany)
    How do glial cells impact neuronal signalling in the thalamus?

    Cynthia Solek (Montreal, QC, Canada)
    The role of microglia-mediated inflammation in neuronal development in vivo

    Sebastien Barbat (Montreal, QC, Canada)
    Aging of the neuromuscular junction: role of glial cells in the modulation and regulation of the motor output

    Kanchan Bisht (Quebec, QC, Canada)
    Dark microglia: a new phenotype implicated in the pathological remodelling of neuronal circuits

    20:00 Dinner
  • Tuesday, 12 April


    Student presentations

    Luisa Lange Canhos (Munich, Germany)
    Self-renewal capacity of reactive astrocytes in vivo

    Víctor Danelon (Córdoba, Argentina)
    Astrocytes mediate neuroprotection in a model of status epilepticus, modulating protease calpain activity in neurons

    Olesia Ignatenko (Helsinki, Finland)
    Knockout of mitochondrial DNA helicase in mouse astrocytes leads to glia activation and spongiotic encephalopathy

    Annamaria Lia (Padua, Italy)
    Exploring the role of astrocyte Ca2+ signaling in Alzheimer's disease

    Laura Civiero (Padua, Italy)
    LRRK2 deficiency in astrocytes impacts neuronal development in vitro

    9:55-10:40 Frank Kirchhoff
    Transgenic mouse models for astrocyte and NG2 glia research
    [30 min + 10 min discussion]
    10:40-11:10 Coffee break

    Student presentations

    Eric Martineau (Montreal, QC, Canada)
    Alteration of glial properties at the NMJ may hinder reinnervation in amyotrophic lateral sclerosis

    Carmen Muñoz-Ballester (Valencia, Spain)
    Astrocytic glutamate uptake is decreased in Lafora disease due to a change in GLT-1 cellular localization

    Eelke Brouwers (Amsterdam, Netherlands)
    Linking deficits in astrocyte chloride channels to disease phenotypes in the white matter disease MLC

    Ambra Del Grosso (Pisa, Italy)
    Galactosylceramidase (GALC) enzymatic activity and psychosine accumulation in central and peripheral nervous system cells and tissues from wild-type and Twitcher mice

    Emma van Kessel (Utrecht, Netherlands)
    Role of glioneuronal transmission and the cerebral glial network in neuro-cognitive functioning in patients with gliomas

    Anna Tishkina (Moscow, Russia)
    Glial changes in response to chronic stress

    Jinar Rostami (Uppsala, Sweden)
    Accumulation and spreading of α-synuclein oligomers in human astrocytes

    Martina Gabrielli (Milan, Italy)
    Active endocannabinoids are released from microglia in association with extracellular vesicles

    12:40-14:00 Lunch break
    14:00-14:45 Gian Michele Ratto
    Making invisible things visible: fluorescent reporters of cellular inner life
    [30 min + 10 min discussion]

    Student presentations

    Bronac Flanagan (Derry, UK)
    Computational modelling of the glutamate (GABA) – glutamine cycle in epilepsy

    Tanja Paavilainen (Tampere, Finland)
    Effects of temporal maturation and development of astrocytes in the functional properties of human neuronal networks in vitro

    Franziska Oschmann (Berlin, Germany)
    A mathematical model of calcium signals in astrocytes induced by uptake of synaptically released glutamate

    Kerstin Lenk (Tampere, Finland)
    Modeling presynapse-astrocyte interactions at network level

    Flora Vasile (Paris, France)
    Astroglial Pannexin hemichannels modulate neuronal network activity

    15:45-19:00 Agora • Preparation (2)
    [with coffee]
    20:00 Dinner
  • Wednesday, 13 April

    9:00-9:45 Elly Hol
    Astrocytes in brain disorders: tools to study molecular and functional changes
    [30 min + 10 min discussion]
    9:45-10:30 Marie-Ève Tremblay
    Structural interactions between microglia and synapses in contexts of neuroinflammation
    [30 min + 10 min discussion]
    10:30-11:00 Coffee break
    11:00-11:45 Giovanni Marsicano
    Roles of astroglial cannabinoid CB1 receptors
    [30 min + 10 min discussion]
    11:45-12:30 Dmitri Rusakov
    Signal integration by astroglia: in search for keys
    [30 min + 10 min discussion]
    12:30-14:00 Lunch break
    14:00 Departure to Ravenna
    Sightseeing and guided tours, followed by dinner
    Return to Bertinoro after dinner
  • Thursday, 14 April

    9:00-9:45 Gian Michele Ratto
    When glia goes bad: glioblastoma
    [30 min + 10 min discussion]
    9:45-10:30 João Filipe Oliveira
    The involvement of astrocytes in cognitive processing
    [30 min + 10 min discussion]
    10:30-11:00 Coffee break
    11:00-11:45 Giorgio Carmignoto
    Unique properties of the astrocyte response to gabaergic interneurons
    [30 min + 10 min discussion]
    11:45-12:30 Giovanni Marsicano
    A cannabinoid link between mitochondria and memory
    [30 min + 10 min discussion]
    12:30-14:00 Lunch break
    14:00-14:45 Frank Kirchhoff
    (Patho)-Physiological properties of astrocytes in vivo
    [30 min + 10 min discussion]
    14:45-15:30 Alfonso Araque
    Circuit-specific synaptic regulation by astrocytes
    [30 min + 10 min discussion]
    15:30-19:00 Agora • Preparation (3)
    [with coffee]
    20:00 Dinner
  • Friday, 15 April

    9:00-9:40 Sebastien Thuault (Senior Editor, Nature Neuroscience)
    An insider’s guide to scientific publishing
    [30 min + 10 min discussion]
    9:40-10:20 Eric Newman
    Astrocyte regulation of blood flow in the CNS: fact or fantasy?
    [30 min + 10 min discussion]
    10:20-11:00 Elly Hol
    Reactive astrocytes in Alzheimer’s disease and stroke: do they affect neuronal communication?
    [30 min + 10 min discussion]
    11:00-11:30 Coffee break
    11:30-12:10 Marie-Ève Tremblay
    Microglial interactions with astrocytes in health and disease
    [30 min + 10 min discussion]
    12:10-12:50 Richard Robitaille
    Decoding the functional state of the neuromuscular junction by glial cells in health and disease
    [30 min + 10 min discussion]
    13:00-14:30 Lunch break
    14:30-19:30 Agora
    [with coffee]
    19:30-20:00 General discussion, Concluding Remarks, Questionnaires
    20:30 Farewell Dinner
  • Saturday, 16 April


Applications: 15 January 2016
Applications are now closed

Notification of selections:
22 January 2016

All applicatants have been notified
of the selection results

Selected applicants must confirm their acceptance by:
29 January 2016

Payment: 26 February 2016

Executive Board

Alfonso Araque
Minneapolis, MN, USA

Giorgio Carmignoto
Padua, Italy

Richard Robitaille
Montréal, QC, Canada

Paulo Magalhães
Padua, Italy

With the support of

Leica Nikon